Actions for the optimal water resources management will be discussed during the “ Freshwater and Culture“ conference with leading experts from National and International Institutions (Universities, municipalities, UN Agencies, etc.) involved in society sustanaibility and resilience. Key focus themes are floods, droughts and landslides among natural and human induced disaster impacting Unesco World Heritage sites, like the beautiful towns of Assisi and Tivoli. Outcomes of the conference will be useful for decision makers to understand and implement best policies and practices paving the way to efficient and safe water quality and quantity management in developed as well as developing countries.